Are shrooms or truffles harmful for the liver?

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I want to try shrooms or truffles, but I am a bit concerned because I got a liver problem and a blood congestion front of my liver. Could this be a big problem ? Thanks for the help.


The mushrooms that contain psilocybin and psilocin will not cause liver damage in healthy persons. I want to stress this fact, because scientific studies were always performed on healthy persons and therefore we’re not in the condition to give any advices on your situation. A doctor should be able to inform you on the (absence of) risks in a more accurate way. 

Nonetheless, this is what the two most important studies concluded on toxicity and blood pressure increase:

  • The toxicity of psilocybin is low. The following study has shown that administration of gradually increasing dosages of psilocybin daily for 21 days had no measurable effect on electrolyte levels, blood sugar levels, or liver toxicity tests.

Passie T, Seifert J, Schneider U, Emrich HM. (2002). “The pharmacology of psilocybin”. Addiction Biology 7 (4): 357–64.

  • Common responses include: pupil dilation (93%); changes in heart rate (100%), including increases (56%), decreases (13%), and variable responses (31%); changes in blood pressure (84%), including hypotension (34%), hypertension (28%), and general instability (22%); changes in stretch reflex (86%), including increases (80%) and decreases (6%); nausea (44%); tremor (25%); and dysmetria (16%) (inability to properly direct or limit motions). The temporary increases in blood pressure caused by the drug can be a risk factor for users with pre-existing hypertension. 

Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX. (2004). “Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study”. Psychopharmacology 172 (2): 145–56