Question:Does MDMA cause permanent damage physically speaking, such as damage to seratonin receptor sites?
It’s been observed through tests on lab animals that large or frequent doses of MDMA can destroy serotonin axons.
The serotonin axons are the ‘communication cables’ that the serotonin system uses to send its signals to the rest of the brain.
MDMA works primarily by causing these serotonin axons to release a lot of serotonin at once, causing that sweet, sweet euphoria.
These poor monkeys (or lucky bastards, depending on your appreciation of MDMA / love for monkeys) showed signs of damaged axons caused by the effects of MDMA. Apparently the axons can ‘grow back’, but this often takes place in other places than they originally were.
Whether this regeneration nullifies the damage is still not entirely clear.
We strongly urge you to read some more scientific material on this matter, this article should be a good start: https://dancesafe.org/drug-information/is-mdma-neurotoxic/.